MyBioSource.com's CLSTN1 Rabbit mAb is a Rabbit monoclonal antibody. The CLSTN1 Rabbit mAb Antibody was generated using Calsyntenin 1 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot.
Description
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity)